Professor Amrik Sahota is involved in three major activities: (i) kidney stone disease; (ii) large-scale genetic studies; and (iii) molecular diagnostics. His lab focuses on the molecular pathology of kidney stone disease, studying the disease process in animal models, in cultured cells and, in collaboration with clinical colleagues, in human renal biopsies. This combined approach has provided, and continues to provide, fundamental insights into the molecular bases of pathological changes, including inflammation, fibrosis, tissue calcification, and cell death. His lab establishes and maintains cell, DNA, and database repositories for complex human diseases and collaborates with other investigators in the identification of genes for these diseases. They continually develop and implement into clinical practice molecular diagnostic assays based on advances in molecular biology and genetics.